The 2024 women’s college basketball tournament is set to tip off as Iowa’s Caitlin Clark seeks to cap off her remarkable college career with a title, but standing in the Hawkeyes’ way is a field of 68 teams featuring, among others, an undefeated South Carolina squad as well as defending champions LSU and perennial powerhouses UConn and Stanford as well as fellow No.1 seeds USC and Texas.
Keep reading to see the pregame lines, spreads and totals from each of the opening round matchups. Catch every game from the First Four to the Final Four and the championship on ABC, ESPN, ESPN2, ESPNU and ESPNEWS.
Odds from Odds by ESPNBET 
as of publication time.
WEDNESDAY — First Four
(16) Presbyterian Blue Hose
(16) Sacred Heart Pioneers -8.5
Colonial Life Arena, Columbia, S.C. , 7 p.m. ET
Presbyterian: 20-14, 8-8 in Big South play
Sacred Heart: 23-9, 15-1 in Northeast play
Money line: Presbyterian (+270) Sacred Heart (-500) Total:116.5
BPI Projection: Sacred Heart by 8.5 points, straight up 78.3% of the time
(12) Columbia Lions -1.5
(12) Vanderbilt Commodores
Cassell Coliseum, Blacksburg, Va., 9 p.m. ET
Columbia: 23-6, 13-1 in Ivy play
Vanderbilt: 22-9, 9-7 in SEC play
Money line: Columbia (-120) Vanderbilt (-115) Total:139.5
BPI Projection: Columbia by 0.5…
