UConn vs. South Carolina odds, prediction: 2025 women’s national championship game picks from proven experts

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The 2025 Women’s NCAA Tournament concludes on Sunday afternoon when the No. 1 seed South Carolina Gamecocks face the No. 2 seed UConn Huskies in the national championship. UConn is coming off a historic 85-51 win over No. 1 seed UCLA in the Final Four, setting the record for largest margin of victory in a Final Four game. South Carolina won the other semifinal game in dominant fashion as well, beating No. 1 seed Texas in a 74-57 final on Friday. These teams met once in the regular season, as UConn cruised to an 87-58 road win on Feb. 16. 

Tipoff is set for 3 p.m. ET on Sunday at Amalie Arena in Tampa. The latest UConn vs. South Carolina odds list the Huskies as 6.5-point favorites, while the over/under is listed at 134.5 points. The Huskies are -310 money line favorites, while the Gamecocks are +250 underdogs. Before making any South Carolina vs. UConn picks, be sure to check out the college basketball predictions from SportsLine experts Calvin Wetzel and Aaron Barzilai.

Barzilai is a Ph.D. from Stanford who served as Director of Basketball Analytics for the Philadelphia 76ers. Wetzel incorporates his mathematical background and strong knowledge of women’s hoops to turn the site’s prediction model into…

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